PhD, University of Pennsylvania
Postdoctoral, North Carolina State University
Office: 2501 Thomas Hall
Website: Visit our Lab Home Page
Research Areas: Molecular / Cell / Development
Using Arabidopsis as a model system, I am investigating the molecular mechanisms behind the phenotypic plasticity of plants. Although the signal integration field in plant biology is still in its infancy, it is becoming increasingly clear that phytohormones are at the center of the signal integration and interpretation process. My lab is utilizing a combination of traditional genetic and modern molecular and genomic approaches to explore the role of two hormones, ethylene and auxin, in the signal integration process in plants. Their previous studies identified a new point of crosstalk between these hormones, induction of auxin biosynthesis by ethylene, and uncovered a previously uncharacterized indole pyruvic acid route of auxin production.
I am continuing the search for the missing components of the ethylene and auxin pathways with the goal to fill in the numerous gaps in the understanding of hormone signaling and response in plants. Recent forward genetic screens in our lab yielded a number of novel mutants affected in their response to ethylene and/or auxin. We are in the process of cloning and characterizing several of these mutant lines in hope to determine their role in the signal integration process in plants.
Stepanova AN, and Alonso JM. (2009). Ethylene Signaling and Response: where different regulatory modules meet. Curr Opin Plant Biol. (in press)
Ikeda Y, Men S, Fischer U, Stepanova AN, Alonso JM, Ljung K, and Grebe M (2009). Local auxin biosynthesis modulates gradient-dependent planar polarity in Arabidopsis. Nature Cell Biol. 11:731–738.
Stepanova AN, Robertson-Hoyt J, Yun J, Benavente LM, Xie D, Dolezal K, Schlereth A, Jurgens G, and Alonso JM. (2008). TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development. Cell. 133: 177–191.
Stepanova AN, Yun J, Likhacheva AV, and Alonso JM. (2007). Multilevel Interactions between Ethylene and Auxin in Arabidopsis Roots. Plant Cell. 19: 2169–2185.
Stepanova AN, Hoyt JM, Hamilton AA, and Alonso JM. (2005). A Link between ethylene and auxin uncovered by the characterization of two root-specific ethylene-insensitive mutants in Arabidopsis. Plant Cell. 17: 2230–42.