PhD, Baylor College of Medicine
Office: 4520 Thomas Hall
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The Mission of the Sikes Lab Group is to investigate the genetic and epigenetic programs that govern lymphocyte development and pathology in order to better understand the central role of differential gene regulation in developmental biology. We believe that such an understanding is critical to realizing the potential of therapies based on stem cells or gene targeting in improving the quality of human health. To that end, we use a variety of animal, cellular, and molecular approaches, coupled with recent advances in genomic and bioinformatics analyses, to map the epigenetic responses of individual gene promoters to developmental and environmental triggers.
Stone, JL, McMillan, RE, Skaar, DA, Bradshaw, JM, Jirtle, RL and Sikes, ML. (2012). DNA double-strand breaks relieve USF-mediated repression of Dbeta2 germline transcription in developing thymocytes. J. Immunol. Jan 27EPub ahead of print. NIHMS: 342559, PMCID: PMC3288432.
Sikes ML and Oltz EM. (2011). Genetic and Epigenetic Control of Antigen Receptor Gene Assembly in Current Topics in Microbiology and Immunology. Curr Top Microbiol Immunol. 356:Jun 18.
Sikes, ML, McMillan, RE and Bradshaw, JM. (2010). The center of accessibility: Dß control of V(D)J recombination. Archivum Immunologiae et Therapiae Experimentalis. 58:427–433. PMCID: PMC3077077.
McMillan, RE and Sikes ML. (2009). Promoter activity 5’ of Dß2 is coordinated by E47, Runx-1, and GATA-3. Mol. Immunol. 46:3009–3017. PMCID: PMC2732994.
Sikes, ML, Bradshaw, JM, Ivory, WT, Lunsford, JL, McMillan, RE, and Morrison, CR. (2009). A streamlined method for rapid and sensitive chromatin immunoprecipitation. J. Immunol. Meth. 15:58–63. PMCID: PMC2692951.
McMillan, RE, and Sikes ML. (2008). Differential activation of dual promoters alters Dß2 germline transcription during thymocyte development. J. Immunol. 180:3218–3228.