Group: Mackay Lab
PhD, Bowling Green State University
Office: 3543 Thomas Hall
Website: Visit our Lab Home Page
Dr. Lyman’s research focuses on the effects of naturally occurring genetic variation on quantitative traits in Drosophila. He is particularly interested in variation in abdominal development and patterning. Differences in abdominal structure and patterning occurs between species of Drosophila and can be used in identifying flies to the species level. What is not clear is how much these differences are the result of speciation or if they are involved in the speciation process itself. To address these issues, Dr. Lyman is looking at variation within a single population of Drosophila melanogaster to identify genes that contribute to the variation. These genes can then be compared to their homologs in other Drosophila species to look at differences between species.
Ayroles JF, Carbone MA, Stone EA, Jordan KW, Lyman RF, Magwire MM, Rollmann SM, Duncan LH, Lawrence F, Anholt RRH, and Mackay TFC. (2009). Systems genetics of complex traits in Drosophila melanogaster. Nat. Genet. 41(2):299–307.
Mackay TFC, and Lyman RF. (2005). Drosophila bristles and the nature of quantitative genetic variation. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360:1513–1527.
Mackay TFC, and Lyman RF. (1998). Polygenic mutation in Drosophila melanogaster: Genotype environment interaction for spontaneous mutations affecting bristle number. Genetica. 102/103: 199–215.
Lyman RF, Lawrence F, Nuzhdin SV, and Mackay TFC. (1996). Effects of single P element insertions on bristle number and viabiltiy in Drosophila melanogaster. Genetics. 143: 293–301.
Mackay TFC, Lyman RF, and Jackson SF. (1992). Effects of P element insertions on quantitative traits in Drosophila melanogaster. Genetics. 130:315–332.