North Carolina State University - Department Of Genetics

Spencer  Muse
Spencer Muse
Program in Genetics


Professor of Statistics

Type: Faculty

PhD, North Carolina State University
Postdoc, Pennsylvania State University

Contact Info
Office: 305 Ricks Hall
T: 919-515-1948
Email: Muse

Website: Visit my Homepage

Research Areas:

My research centers on the development of statistical methods and software for studying processes of molecular evolution. Historically, my work has explored a variety of applications where simple stochastic models of sequence evolution were not sufficient, and that theme continues to this day. My current work includes: (i) model selection techniques and multi-model inferential procedures to estimate evolutionary parameters; (ii) modeling heterogeneity of silent substitution rates across genes, sites, and lineages; and (iii) continued development of the HyPhy molecular evolutionary analysis platform.

Selected Publications:

Kosakovsky Pond SL, Delport W, Muse SV, and Schffler K. (2010). Correcting the bias of empirical frequency parameter estimators in codon models. PLoS ONE. 5:e11230.

Gibson GG, and Muse SV. (2009). A Primer of Genome Science–3rd edition. Sinauer

Kosakovsky Pond SL, and Muse SV. (2005). Modeling heterogeneity of synonymous and nonsynonymous nucleotide substitution rates across sites. Mol. Biol. Evol. 22(12):2375–2385.

Muse SV. (1996). Estimating synonymous and nonsynonymous nucleotide substitution rates. Mol. Biol. Evol. 13:105–114.

Muse SV, and Gaut BS. (1994). A likelihood approach for comparing synonymous and nonsysnonymous nucleotide substitution rates with application to the chloroplast genome. Mol. Biol. Evol. 11:715–724.

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Program in Genetics
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N.C. State University
Raleigh, NC 27695-7614