Graduate Courses Offered

GN 521 Molecular Genetics 3.
Prerequisite: GN 311.

Biological macromolecules and their interactions, DNA topology, eukaryotic genome structure, chromatin and chromosome structure, transcription and transcription regulation, epigenetics, RNAi and RNA processing, recombinant DNA technology, genetic transformation and cloning of plants and animals. Bacteria, viruses, plants, animals, and fungi as genetic systems. Students cannot receive credit for both GN 421 and GN 521.

GN 541 Human and Biomedical Genetics 3.

This course is an in-depth study of human and biomedical genetics and the role of genetics in human health and disease. The course will acquaint students with contemporary knowledge of genetics in disease causation and susceptibility, the use of model organisms to inform human biology and contemporary topics in human genetics research like epigenetics, therapeutic cloning, gene therapy, the role of genetics in response to drugs and predictive medicine. Credit cannot be given for both 441 and 541.

GN 685 Master’s Supervised Teaching 1-3.
Prerequisite: Master’s student.

Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.

GN 690 Master’s Examination 1-9.
Prerequisite: Master’s student.

For students in non-thesis master’s programs who have completed all other requirements of the degree except preparing for and taking the final master’s exam.

GN 693 Master’s Supervised Research 1-9.
Prerequisite: Master’s Student.

Instruction in research and research under the mentorship of a member of the Graduate Faculty.

GN 695 Master’s Thesis Research 1-9.
Prerequisite: Master’s Student.

Thesis Research.

GN 696 Summer Thesis Research 1.
Prerequisite: Master’s student.

For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.

GN 699 Master’s Thesis Preparation 1-9.
Prerequisite: Master’s Student.

For students who have completed all credit hour requirements and full-time enrollment for the master’s degree and are writing and defending their thesis.

GN 701 Molecular Genetics 3.
Prerequisite: GN 311.

A discussion of the structure and function of genetic material at a molecular level. Consideration of both prokaryotic and eukaryotic systems. The aim to describe genetics in terms of chemical principles.

GN 702 Cellular and Developmental Genetics 3.
Prerequisite: GN 701.

Regulation of genes involved in cellular function, differentiation and development in eukaryotes. Presentation of biological systems and model organisms used to study the genetic control of cellular and developmental processes.

GN 703 Population and Quantitative Genetics 3.
Prerequisite: GN 311 and ST 512.

Mutation and origin of genetic variation. Measuring genetic variation in natural populations. Gene and genotype frequencies. Hardy-Weinberg equilibrium. Values, means, genetic and environmental variance, heritability of quantitative traits. Random genetic drift and inbreeding. Natural and artificial selection. Theory and tests of models of maintenance of genetic variation. Molecular evolution of genes and proteins. Genome evolution.

GN 708 Genetics of Animal Improvement 3.
Prerequisite: GN 311ST 512.

Emphasis on the utilization of basic principles of population and quantitative genetics in animal improvement. Factors affecting genic and genotypic frequencies and methods of estimating genetic and nongenetic variance, heritabilities and breeding values. The roles of mating systems and selection procedures in producing superior genetic populations.

GN 713 Quantitative Genetics and Breeding 3.

Quantitative and population genetic theory of breeding problems; partitioning of genetic variance, maternal effects, genotype by environment interaction and genetic correlation; selection indexes; design and analysis of selection experiments; marker-assisted selection.

GN 720 Molecular Biology In Plant Breeding 3.
Prerequisite: CS(GN,HS) 741, GN 701.

Theory and principles of molecular biology applied to plant breeding. Experimental approaches to induce genetic change, cytoplasmic recombination, haploid utilization and potentials of molecular techniques for solving breeding problems.

GN 721 Genetic Data Analysis 3.
Prerequisite: ST 430 and GN 311.

Analysis of discrete data, illustrated with genetic data on morphological characters allozymes, restriction fragment length polymorphisms, and DNA sequences. Maximum likelihood estimation, including iterative procedures. Numerical resampling. Development of statistical techniques for characterizing genetic disequilibrium and diversity. Measures of population structure and genetic distance. Construction of phylogenetic trees. Finding alignments and similarities between DNA sequences. Locating genes with markers.

GN 725 Forest Genetics 3.
Prerequisite: GN 311.

Application of genetic principles to silviculture, management, and wood utilization. Emphasis on variation in wild populations, the bases for selection of desirable qualities and fundamentals of controlled breeding.

GN 730 Fungal Genetics and Physiology 3.
Prerequisite: BCH 451, BO 775, GN 311 or PP 501.

Basic concepts of genetics and physiology of fungi, with emphasis on saprophytic and plant pathogenic mycelial fungi. Current literature on evolution, cell structure, growth and development, gene expression, metabolism, sexual and asexual reproduction and incompatibility systems. Laboratory exercises on mutant isolation, sexual and parasexual analysis, genetic transformation, and RFLP and isozyme analysis.

GN 735 Functional Genomics 3.
Prerequisite: GN 701.

Methodology of experimental genomics; genome sequencing, gene expression arrays, genomic screens, proteomics. Aims and achievements of microbial, plant, animal, human genome projects. Applications of genomics including parasitology, breeding, functional genomics, evolutionary genetics. Interface with bioinformatics, data technology.

GN 740 Evolutionary Genetics 3.
Prerequisite: GN 703.

Genetic basis of evolution. Molecular evolution, molecular population genetics, evolutionary genetics of quantitative characters and the genetics of speciation. Critical reading of original research publications and student seminars.

GN 745 Quantitative Genetics In Plant Breeding 1.
Prerequisite: CS(GN, HS) 741, ST 512, course in quantitative genetics recommended.

Theory and principles of plant quantitative genetics. Experimental approaches to relationships between type and source of genetic variability, concepts of inbreeding, estimations of genetic variance and selection theory.

GN 746 Breeding Methods 2.
Prerequisite: CS (GN, HS) 741, ST 512.

Theory and principles of plant breeding methodology including population improvement, selection procedures, genotypic evaluation, cultivar development and breeding strategies.

GN 750 Developmental Genetics 3.
Prerequisite: GN 701GN 702.

Action and regulation of genes and gene-products in development and differentiation. Examples of microorganisms, plants, and animals. Emphasis on molecular and biochemical aspects of mechanisms controlling gene expression in eukaryotic cell differentiation.

GN 755 Population Genetics 3.
Prerequisite: GN 703.

Theoretical population genetics and its relationship to natural and experimental populations. Single locus and multilocus systems, history of a gene in a population, diffusion approximations, suitability of models to natural and experimental populations.

GN 756 Computational Molecular Evolution 3.
Prerequisite: GN 311 and ST 511.

Phylogenetic analyses of nucleotide and protein sequence data. Sequence alignment, phylogeny reconstruction, and relevant computer software. Prediction of protein secondary structure, database searching, bioinformatics and related topics. Project required.

GN 757 Statistics for Molecular Quantitative Genetics 3.
Prerequisite: ST 512 and GN 703 or ST 721.

Genetic mapping data. Linkage map reconstruction, quantitative genetical models. Statistical methods and computer programs for mapping quantitative trait loci and estimating genetic architecture of quantitative traits.

GN 758 Microbial Genetics & Genomics 3.
Prerequisite: BCH 451 or GN 311.

Structure and function in microbial genetics, with emphasis on microbial genome organization, stable maintenance, and evolution. DNA mutation and repair pathways, transcriptional and translational regulation, DNA replication and recombination and characterization of recombinant DNA molecules. Applications of genetic and genomic analysis methods to microbial processes, including strain construction, genome manipulation, and enhancement of gene expression.

GN 761 Advanced Molecular Biology Of the Cell 3.
Prerequisite: BCH 553 or BCH 703 or GN 701.

An advanced graduate class involving integrated approaches to complex biological questions at the molecular level, encompassing biochemistry, cell biology, and molecular genetics. The course will focus on an important, current area of research in eukaryotic biology using the primary scientific literature, and will involve class discussions, oral presentations, and a written research proposal.

GN 768 Nucleic Acids: Structure and Function 3.
Prerequisite: BCH 701 and 703.

An advanced treatment involving integrated approaches to biological problems at the molecular level, encompassing biochemistry, cell biology, and molecular genetics. Broad, multidisciplinary approaches to solving research problems in biology and theoretical study of primary scientific literature, the development of a research proposal, oral presentations and class discussions.

GN 801 Seminar 1.
Prerequisite: Graduate standing.

Informal group discussion of prepared topics assigned by the instructor.

GN 810 Special Topics in Genetics 1-6.

Critical study of selected areas and special topics of current interest in genetics and related fields.

GN 820 Special Problems 1-6.
Prerequisite: Advanced Graduate standing.

Special topics designed for additional experience and research training.

GN 850 Professionalism and Ethics 1.
Prerequisite: Graduate standing.

The course is designed to give students a background in professionalism, scientific ethics and responsible conduct of science. Topics include the role of the scientist in society, ethical theory, data acquisition and ownership, scientific misconduct, authorship, peer review, conflicts of interest and commitment, intellectual property, ethics of teaching and mentoring, ethical treatment of animal and human subjects, ethics of genetics research, job hunting and interviewing.

GN 860 Plant Breeding Laboratory 1.
Prerequisite: CS(GN,HS)741.

Visitation of plant breeding projects in the Depts. of CS and HS at NC State, along with commercial seed companies. Discussion and viewing of breeding objectives, methods and equipment and teaching and practice of hybridization methods.

GN 861 Plant Breeding Laboratory 1.
Prerequisite: CS(GN,HS)741.

Visitation of plant breeding projects in the Depts. of CS and HS at NC State, along with commercial seed companies. Discussion and viewing of breeding objectives, methods and equipment and teaching and practice of hybridization methods.

GN 885 Doctoral Supervised Teaching 1-3.
Prerequisite: Doctoral student.

Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.

GN 890 Doctoral Preliminary Examination 1-9.
Prerequisite: Doctoral student.

For students who are preparing for and taking written and/or oral preliminary exams.

GN 893 Doctoral Supervised Research 1-9.
Prerequisite: Doctoral student.

Instruction in research and research under the mentorship of a member of the Graduate Faculty.

GN 895 Doctoral Dissertation Research 1-9.
Prerequisite: Doctoral student.

Dissertation Research.

GN 896 Summer Dissertation Research 1.
Prerequisite: Doctoral student.

For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.

GN 899 Doctoral Dissertation Preparation 1-9.
Prerequisite: Doctoral student.

For students who have completed all credit hour requirements, full-time enrollment, preliminary examination, and residency requirements for the doctoral degree, and are writing and defending their dissertations.