North Carolina State University - Program Of Genetics

David M. Reif
David M. Reif
Program in Genetics


Associate Professor of Biological Sciences

Type: Faculty

Postdoc, U.S. Environmental Protection Agency
PhD, Vanderbilt University
MS, Vanderbilt University
BS, College of William & Mary

Contact Info
Office: Broughton Hall 4219
Phone: 919-513-3812
Email: dmreif


Research Areas: Computation / Bioinformatics

I joined North Carolina State University in January 2013 as an Associate Professor in the Program in Genetics and a resident member of the Bioinformatics Research Center. My overarching research goal is to understand the complex interactions between human health and the environment through the integrated analysis of high-dimensional data from diverse sources, including epidemiological studies of human health, high-throughput screening (HTS) of environmental chemicals, and model organism data. To accomplish this goal, I focus on analytical/visual methods development, experimental design, and software implementation. Prior to joining NCSU, I was a Principal Investigator (PI) with the U.S. EPA's National Center for Computational Toxicology, where I led several statistical/bioinformatical efforts at the Agency and collaborated on a variety of projects with federal, academic, and industry partners.

Selected Publications:

Link to all publications:

Kleinstreuer NC, Yang J, Berg EL, Knudsen TB, Richard AM, Martin MT, Reif DM, Judson RS, Polokoff M, Dix DJ, Kavlock RJ, Houck KA. Phenotypic screening of the toxcast chemical library to classify toxic and therapeutic mechanisms. Nature Biotechnology. [Accepted - In press]

Truong L, Reif DM, St Mary L, Geier MC, Truong HD, Tanguay RL. Multidimensional In Vivo Hazard Assessment Using Zebrafish. Toxicological Sciences. 2014; 137 (1), 212-233.

Reif DM, Sypa M, Lock EF, Wright FA, Wilson A, Cathey T, Judson RS, Rusyn I. ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics. 2013; 29 (3), 402-403.

Padilla S, Corum D, Padnos B, Hunter DL, Beam A, Houck KA, Sipes N, Kleinstreuer N, Knudsen T, Dix DJ, Reif DM. Zebrafish developmental screening of the ToxCastTM Phase I chemical library. Reprod Toxicol. 2012 Apr;33(2):174-87.

Joubert BR, Reif DM, Edwards SW, Leiner KA, Hudgens EE, Egeghy P, Gallagher JE, Hubal EC. Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population. BMC Med Genet. 2011 Feb 14;12:25.

Reif DM, Martin MT, Tan SW, Houck KA, Judson RS, Richard AM, Knudsen TB, Dix  DJ, Kavlock RJ. Endocrine profiling and prioritization of environmental chemicals using ToxCast data. Environ Health Perspect. 2010 Dec;118(12):1714-20.

Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS. Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicol Sci. 2010 Oct;117(2):348-58.

Judson RS, Martin MT, Reif DM, Houck KA, Knudsen TB, Rotroff DM, Xia M, Sakamuru S, Huang R, Shinn P, Austin CP, Kavlock RJ, Dix DJ. Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. Environ Sci Technol. 2010 Aug 1;44(15):5979-85.

Judson RS, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Mortensen HM, Reif DM, Rotroff DM, Shah I, Richard AM, Dix DJ. In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. Environ Health Perspect. 2010 Apr;118(4):485-92.

Reif DM, Motsinger-Reif AA, McKinney BA, Rock MT, Crowe JE Jr, Moore JH. Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination. Genes Immun. 2009  Mar;10(2):112-9.

Reif DM, McKinney BA, Motsinger AA, Chanock SJ, Edwards KM, Rock MT, Moore JH, Crowe JE. Genetic basis for adverse events after smallpox vaccination. J Infect Dis. 2008 Jul 1;198(1):16-22.

Motsinger AA, Ritchie MD, Reif DM. Novel methods for detecting epistasis in pharmacogenomics studies. Pharmacogenomics. 2007 Sep;8(9):1229-41.

Wilke RA, Reif DM, Moore JH. Combinatorial pharmacogenetics. Nat Rev Drug Discov. 2005 Nov;4(11):911-8.

Reif DM, Dudek SM, Shaffer CM, Wang J, Moore JH. Exploratory visual analysis  of pharmacogenomic results. Pac Symp Biocomput. 2005:296-307.

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Program in Genetics
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