PhD, University of Toronto, Canada
Office: 233 Partners III, Centennial Campus
Website: Visit our Lab Home Page
A major focus of our research is understanding the evolutionary and genetic mechanisms regulating aflatoxigenicity. Aflatoxin is one of the most carcinogenic compounds known and is responsible for major yield losses in oil seed crops worldwide. We examine the genetic and genomic mechanisms that generate aflatoxin diversity in populations of Aspergillus flavus and A. parasiticus obtained from experimental crosses in the laboratory and from population sampling on a global scale. We are interested in the genetic basis of fertility in these fungi, genotype-toxin associations and in characterizing the genetic and genomic plasticity observed in experimentally evolved populations in the laboratory and in nature. Our goal is to apply our knowledge of the evolutionary and genetic processes that influence aflatoxigenicity in these species to the development of novel biocontrol measures.
Bradshaw RE, Slot JC, Moore GG, Chettri P, de Wit PJGM, Ehrlich KC, Ganley ARD, Olson MA, Rokas A, Carbone I, and Cox MP. (2013). Fragmentation of an aflatoxin-like gene cluster in a forest pathogen. New Phytologist. 198:525–535.
Wei W, Ayub Q, Chen Y, McCarthy S, Hou Y, Carbone I, Xue Y, and Tyler-Smith C. (2013). A calibrated human Y-chromosomal phylogeny based on resequencing. Genome Research. 23:388–395.
Olarte RA, Horn BW, Dorner JW, Monacell JT, Singh R, Stone EA, and Carbone I. (2012). Effect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis. Molecular Ecology. 21:1453–1476.
Litvintseva AP, Carbone I, Rossouw J, Thakur R, Govender NP, and Mitchell TG. (2011). Evidence that the human pathogenic fungus Cryptococcus neoformans var. grubii may have evolved in Africa. PLoS One. 6(5):e19688. doi:10.1371/journal.pone.0019688.
Carbone I, Jakobek JL, Ramirez-Prado JH, and Horn BW. (2007). Recombination, balancing selection and adaptive evolution in the aflatoxin gene cluster of Aspergillus parasiticus. Molecular Ecology. 16:4401–4417.
Price EW, and Carbone I. (2005). SNAP: workbench management tool for evolutionary population genetic analysis. Bioinformatics. 21:402–404.