North Carolina State University - Program Of Genetics

William R. Atchley
William R. Atchley
Program in Genetics


William Neal Reynolds Distinguished Professor of Genetics and Associate Member of Statistics

Type: Emeritus Faculty

PhD, University of Kansas
Postdoctoral, University of Melbourne

Contact Info
Office: 2560 Thomas Hall, 919-515-7088
Lab: 2560 Thomas Hall, 919-515-5759
Fax: 919-515-3355

Website: Visit our Lab Home Page

Computational biology and molecular evolution

The major thrust of my research lies in computational biology and deals with broad questions in molecular evolution. I am particularly interested in modeling structure and evolution of transcriptional regulators, exploring the origin and evolution of regulatory gene networks, and the application of multivariate statistical methods to high dimensional molecular data.

Selected Publications:

Atchley WR, Zhao J, Fernandes A, and Drueke T. (2005). Solving the sequence "metric" problem. Proc Natl Acad Sci USA. 102: 6395–6400. [pdf Reprint]

Atchley WR, and Fernandes A. (2005). Sequence signatures and the probabilistic identification of proteins in the Myc-Max-Mad network. Proc Natl Acad Sci USA. 102: 6401–6406. [pdf Reprint]

Buck MJ, and Atchley WR. (2005). Networks of coevolving sites in structural and functional domains of serpin proteins. Mol Biol Evol. 22:1627–1634. [pdf Reprint]

Buck MJ, and Atchley WR. (2003). Phylogenetic analysis of plant basic helix-loop-helix proteins. J Mol Evol. 56: 742–750. [pdf Reprint]

Atchley WR, Lokot T, Wollenberg K, Dress A, and Ragg H. (2001). Phylogenetic analyses of amino acid variation in the serpin proteins. Mol Biol Evol. 18: 1502–11. [pdf Reprint ]

Ragg H, Lokot T, Kamp PB, Atchley WR, and Dress A. (2001). Vertebrate serpins: construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. Mol Biol Evol. 18: 577–84. [pdf Reprint ]

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Program in Genetics
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N.C. State University
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