David Aylor

Associate Professor

 

Research Interests

We study how genetic variation controls complex traits, susceptibility to disease, and individual molecular biology. Most prevalent human diseases, most agriculturally important traits, and evolutionary fitness are complex traits, which means they are influenced by a combination of multiple genetic and environmental factors. A long-standing goal in the field is to identify quantitative trait loci (QTL) – genetic variants that influence complex traits. Discovering these relationships is challenging because the individual factors each have small effects, and because genetic variants often interact with the environment (GxE) or other genes (epistasis). Figuring out how these variants change the function of cells or molecules has been even more difficult. Understanding these genetic mechanisms will enable the translation of model organism research to humans and uncover new principles of genetics and genome science. We develop and apply systems genetics approaches that enable us to discover QTL and reveal their mechanisms.


Courses Taught

Information coming soon.


Selected Publications

Impact of low-dose oral exposure to bisphenol A (BPA) on Juvenile and adult rat exploratory and anxiety behavior: A CLARITY-BPA Consortium Study
ME Rebuli, L Camacho, ME Adonay, DM Reif, DL Aylor, HB Patisaul
Toxicological Sciences 148 (2), 341-354 17 2015

A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2
JP Didion, AP Morgan, AMF Clayshulte, RC Mcmullan, L Yadgary, …
PLoS genetics 11 (2), e1004850 17 2015

Integrative genetic analysis of allergic inflammation in the murine lung
SNP Kelada, DE Carpenter, DL Aylor, P Chines, H Rutledge, EJ Chesler, …
American journal of respiratory cell and molecular biology 51 (3), 436-445 16 2014

Genetically determined severity of anti-myeloperoxidase glomerulonephritis
H Xiao, D Ciavatta, DL Aylor, P Hu, FPM de Villena, RJ Falk, JC Jennette
The American journal of pathology 182 (4), 1219-1226 15 2013

Genetic regulation of Zfp30, CXCL1, and neutrophilic inflammation in murine lung
H Rutledge, DL Aylor, DE Carpenter, BC Peck, P Chines, LE Ostrowski, …
Genetics 198 (2), 735-745 14 2014

Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross
JR Shorter, F Odet, DL Aylor, W Pan, CY Kao, CP Fu, AP Morgan, …
Genetics 206 (2), 557-572 5 2017

The founder strains of the collaborative cross express a complex combination of advantageous and deleterious traits for male reproduction
F Odet, W Pan, TA Bell, SG Goodson, AM Stevans, Z Yun, DL Aylor, …
G3: Genes, Genomes, Genetics 5 (12), 2671-2683


 

David Aylor